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Generic brands of lisinopril, and no differences were seen between any of the study drugs and placebo. Patients on pravastatin fluvastatin experienced a very significant increase in risk for heart attack compared with those taking a placebo."
"A total of 1,937 patients were included in the study, of which 1,069 were men and 934 women, followed for an average of 8.2 years."
The study was published in journal Heart. summary, pravastatin had no effect on cardiovascular events in patients with type 2 diabetes.
"The most common adverse events that were reported by patients receiving pravastatin were cardiovascular events (heart attack, stroke, and MI), including myocardial infarction, angina, angioplasty, coronary revascularization, chest pain/trigeminal neuralgia, and ventricular arrhythmias."
"The most common adverse events that were reported by patients receiving placebo were psychiatric events (including nausea, vomiting, insomnia, anxiety, and nervousness) pain during treatment."
In the end, there were no significant differences between the three study drugs.
Conclusion: There was no difference in cardiovascular risk between the three drugs for patients with type 2 diabetes.
DHEA for Heart Failure
DHEA is an essential hormone for the heart's metabolism. It is also a critical factor in the regulation of blood pressure.
A major study found the following:
"Two independent clinical trials of pyridoxal 5'-phosphate (PPP), [a supplement of DHEA] and placebo, have demonstrated significant reductions in the rate of hospitalizations for congestive heart failure, with no significant difference between the two treatments."
"A total of 7,856 participants [with congestive heart failure] were enrolled in these trials, of which 2,400 had the diagnosis of CHF at baseline."
"The primary endpoints, the incidence and rate of hospitalizations for CHF, were evaluated between both PPP and placebo groups for a mean follow-up of 5.2 years. The primary outcome and associated rates were not affected by the use of placebo, with exception a higher rate of hospitalization for CHF in the PPP group (11.4 vs. 9.6 per 1,000 person-years; P=0.07). The rate ratios of primary outcomes [the number hospitalizations for CHF per 1,000 person-years in the PPP group vs. placebo group] were 2.4 (95% CI: 1.3-4.8) for hospitalization CHF, which was inversely associated with sex and age, 2.7 (95% CI: 1.0-7.7) for hospitalizations MI, which was not. For both of the secondary endpoints, rate ratio for CHF was 1.7 (95% CI: 0.9-2.3) for hospitalizations CHF and 1.8 (95% CI: 1.0-3.2) for hospitalizations MI, which was not.
The median follow-up of 2 trials was 5.8 years, and the median number of hospitalizations for CHF was 8.4 (range: 1-54) and for MI was 3 (range: 0-17) per 1,000 person-years."
Conclusion: The authors found no difference between DHEA and placebo in the reduction of risk hospitalizations for heart failure, and no significant difference between the two treatment groups. Although, in the study of patients with type 2 diabetes, there was a slight decrease in the incidence of heart failure, it was not significant compared to placebo.
Conclusion: DHEA was not significantly different than placebo in preventing or controlling the onset of heart failure in patients with type 2 diabetes.
DHEA for Hypertension
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DHEA in patients with hypertension found no significant difference.
The following is a quote from review by the American College of Cardiology (ACC) on the use of DHEA for treatment hypertension:
"The results of this study have been reviewed for the purpose of improving medical decision making physicians and the public by clarifying risks relative to the benefits of DHEA and need to use caution when using DHEA."
"There were no significant differences in the number of patients who had a cardiovascular event when comparing anodal DHEA and placebo. After 6 years of follow-up, the number patients with cardiovascular events was not significantly different between anodal DHEA and placebo in either the anodal or placebo arms."
"The majority of studies have reported benefit in preventing cardiovascular disease events among patients with hypertension. However, the benefit is not consistently demonstrated. In"
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The most probable mode of action may be the inhibition of vascular smooth muscle activity. We is there a generic brand for lisinopril
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